Lembehyne A, a Novel Neuritogenic Polyacetylene, from a Marine Sponge of Haliclona sp.

Lembehyne A (1), a novel long chain polyacetylene, which induces neurite outgrowth, was isolated from a Indonesian marine sponge of Haliclona sp. The total structure of 1 was determined by spectroscopic study, chemical degradation, and modified Mosherʹs method. Lembehyne A induced neuritogenesis in pheochromocytoma PC12 cells and neuroblastoma Neuro 2A cells at 2 and 0.1 μg/mL, respectively.