Title of article
Stereoselective synthesis of 2,6-dideoxy; 3,6-dideoxy; 2,3,6-trideoxy-inositol 1,4,5-trisphosphate and 6-deoxy-inositol 1,3,4,5-tetrakisphosphate analogues from 6-deoxy-d-inositol precursors
Author/Authors
Alo??sio Antonio Alves Ben??cio، نويسنده , , Adilson David Da Silva، نويسنده , , Mauro Vieira de Almeida، نويسنده , , Maria Mirtes Da Silva، نويسنده , , Stéphane Dov Gero، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
7
From page
1161
To page
1167
Abstract
The novel 2,6-dideoxy-2,2-difluoro; 2,6-dideoxy-2-fluoro; and 2,3,6-trideoxy-2,3-difluoro-Ins(1,4,5)tris(dibutyl)phosphates and 6-deoxy-d-chiro-inositol 1,3,4,5-tetrakis(dibutyl)phosphate analogues were synthesized in optically pure form. Modification of Ins(1,4,5)P3 and Ins(1,3,4,5)P4 analogues by lipophilic substituents has been investigated in order to produce neutral phosphate derivatives aimed to be incorporated in cell membrane for in vivo evaluation.
Keywords
inositol 1 , 4 , 5-trisphosphate , phosphoinositide cascade , lipophilic substituents
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1081675
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