• Title of article

    Molecular modeling of 5-desacetylaltohyrtin A, a spongean cytotoxic macrolide

  • Author/Authors

    Shunji Aoki، نويسنده , , Nobuaki Nemoto، نويسنده , , Yuji Kobayashi، نويسنده , , Motomasa Kobayashi، نويسنده , , Isao Kitagawa، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2001
  • Pages
    4
  • From page
    2289
  • To page
    2292
  • Abstract
    The solution structure of 5-desacetylaltohyrtin A, an extremely cytotoxic macrolide isolated from a marine sponge, was analyzed by NMR and restrained molecular dynamics. The average value of pairwise RMSD for the backbone (from C1 to C43) of the 10 lowest energy structures was 0.50±0.22 Å. The stereostructure of C14–C16 in 5-desacetylaltohyrtin A was further verified by restrained molecular dynamic calculation using incorrect chiral restraints.
  • Keywords
    macrolide , Marine sponge , Cytotoxic , altohyrtin A , Molecular modeling
  • Journal title
    Tetrahedron
  • Serial Year
    2001
  • Journal title
    Tetrahedron
  • Record number

    1081805

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1081805