Title of article
A convergent asymmetric synthesis of γ-butenolides
Author/Authors
Marc Renard، نويسنده , , Léon A. Ghosez، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
12
From page
2597
To page
2608
Abstract
The addition of aldehydes to the new enantiomerically pure lithiated sulfoxide-orthoester 13 yielded γ-butenolides of high enantiomeric purities after elimination of phenylsulfinic acid. The cyclocondensation with ketones was less stereoselective. This new asymmetric synthesis of γ-butenolides has been applied to a convergent preparation of the antifungal antibiotic (+)-cerulenin.
Keywords
Cyclocondensation , ?-butenolides , cerulenin , Asymmetric synthesis , sulfoxides
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1081842
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