Title of article
Design, modeling and synthesis of functionalized paromamine analogs
Author/Authors
Stephen Hanessian، نويسنده , , Martin Tremblay، نويسنده , , Alexander Kornienko، نويسنده , , Nicolas Moitessier، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
11
From page
3255
To page
3265
Abstract
Based on the published NMR structure of the antibiotic paromomycin complexed with the A-site of Escherichia coli 16S ribosomal RNA, a set of C-5 functionalized analogs of paromamine was designed and synthesized, incorporating cyclic and acyclic appendages and terminating with one or more ammonium groups.
Keywords
Aminoglycoside , RNA , Paromomycin , Modeling , Library
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1081907
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