Title of article :
Synthesis of a new structural analogue of (+)-porothramycin
Author/Authors :
Anne Rojas-Rousseau، نويسنده , , Nicole Langlois، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
A new phosphonate analogue of (+)-porothramycin has been synthesized from (S)-pyroglutaminol. Circular dichroism of diastereomeric intermediates 9 has been studied. The cytostatic activity of the new pyrrolo[2,1-c][1,4]benzodiazepine has been evaluated against human KB cells.
Keywords :
4]benzodiazepines , phosphonate , circular dichroism , Cytotoxicity , Horner–Wadsworth–Emmons reaction
Journal title :
Tetrahedron
Journal title :
Tetrahedron
