Title of article
Synthesis of a common key intermediate for (−)-tetrodotoxin and its analogs
Author/Authors
Toshio Nishikawa، نويسنده , , Masanori Asai، نويسنده , , Norio Ohyabu، نويسنده , , Noboru Yamamoto، نويسنده , , Yoshio Fukuda، نويسنده , , Minoru Isobe and Kunio Miki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
9
From page
3875
To page
3883
Abstract
A key intermediate for tetrodotoxin and its analogs such as (−)-5,11-dideoxytetrodotoxin was stereoselectively synthesized from a chiral starting material, levoglucosenone, via Diels–Alder reaction and the Overman rearrangement as key steps. The Overman rearrangement of the precursor bearing hydroxy group of C-8 was also described.
Keywords
Tetrodotoxin , Diels–Alder reaction , Overman rearrangement , Levoglucosenone , A-strain
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1081971
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