Title of article :
Synthesis of a common key intermediate for (−)-tetrodotoxin and its analogs
Author/Authors :
Toshio Nishikawa، نويسنده , , Masanori Asai، نويسنده , , Norio Ohyabu، نويسنده , , Noboru Yamamoto، نويسنده , , Yoshio Fukuda، نويسنده , , Minoru Isobe and Kunio Miki، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
A key intermediate for tetrodotoxin and its analogs such as (−)-5,11-dideoxytetrodotoxin was stereoselectively synthesized from a chiral starting material, levoglucosenone, via Diels–Alder reaction and the Overman rearrangement as key steps. The Overman rearrangement of the precursor bearing hydroxy group of C-8 was also described.
Keywords :
Tetrodotoxin , Diels–Alder reaction , Overman rearrangement , Levoglucosenone , A-strain
Journal title :
Tetrahedron
Journal title :
Tetrahedron
