Author/Authors :
Angel C Ramos، نويسنده , , Rafael Pelaez Lamamie de Clairac، نويسنده , , Jose Luis L?pez، نويسنده , , Esther Caballero، نويسنده , , Manuel Medarde، نويسنده , , Arturo San Feliciano، نويسنده ,
Abstract :
The conjugate addition–alkylation to 5H-furan-2-one followed by cyclization and controlled epimerizations have been applied to the synthesis of new furo- and thieno-lignan analogues. Podophyllotoxin and thuriferic acid heteroanalogues have been obtained by this methodology, as representative members of these families.
Keywords :
Lignans , Thiophenes , antitumour compounds , Furans
