Title of article :
Unusual polyoxygenated sterols from a Philippines sponge Xestospongia sp.
Author/Authors :
Melissa L Lerch، نويسنده , , D.John Faulkner، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
Two novel sulfated sterols, ibisterol sulfates B (3) and C (4), and an unprecedented non-sulfated sterol, 4β,5β-epoxy-2β,3α,12β,22S-tetrahydroxy-14α-methylcholest-7,9(11)-dien-6,24-dione (5) have been isolated from a Xestospongia sp. collected in the Philippines. The structures were elucidated using spectroscopic data. These sterols were found to be inhibitors of HIV-1 integrase.
Keywords :
sterol , marine natural products , Xestospongia sp , Cytotoxicity , HIV-1 integrase
Journal title :
Tetrahedron
Journal title :
Tetrahedron
