Title of article
An expeditious synthesis of pentosidine, an advanced glycation end product
Author/Authors
Fumiaki Yokokawa، نويسنده , , Hideyuki Sugiyama، نويسنده , , Takayuki Shioiri، نويسنده , , Noriko Katagiri، نويسنده , , Osamu Oda، نويسنده , , Hiroshi Ogawa، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
8
From page
4759
To page
4766
Abstract
The chemical synthesis of pentosidine (1), an advanced glycation end product, was achieved via the asymmetric alkylation of the chiral schiff base derived from (+)-2-hydroxy-3-pinanone ((+)-HyPN) and glycine tert-butyl ester, the mercury salt mediated intramolecular guanylation, and the regioselective alkylation of imidazo[4,5-b]pyridine ring. This reliable synthetic achievement will promise availability of pentosidine (1) in quantities.
Keywords
Quaternization , Pentosidine , an advanced glycation end product , asymmetric alkylation , 5-b]pyridine
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082065
Link To Document