Author/Authors :
Vincent Dumontet، نويسنده , , Christiane Gaspard، نويسنده , , Nguyen Van Hung، نويسنده , , Jacques Fahy، نويسنده , , Luba Tchertanov، نويسنده , , Thierry Sévenet، نويسنده , , Françoise Guéritte-Voegelein، نويسنده ,
Abstract :
A new dihydrochalcone, two new dihydroflavanones and eight new biflavonoids have been isolated together with cryptocaryone from the cytotoxic methanol extract of Cryptocarya infectoria. The absolute structure of cryptocaryone was established by X-ray analysis of its 8-bromo derivative. The structure of the new compounds were elucidated by spectroscopic means and their absolute stereochemistry was deduced from chemical correlation, circular dichroism data and NOESY experiments. Several compounds displayed significant cytotoxicity and cryptocaryone was shown to possess cytotoxicity towards multi-drug resistant K562-DOX cells.
