Title of article
Rationalising diastereoselection in the dynamic kinetic resolution of α-haloacyl imidazolidinones: a theoretical approach
Author/Authors
A Gil Santos، نويسنده , , Sara X Candeias، نويسنده , , Carlos A.M Afonso، نويسنده , , Kerry Jenkins، نويسنده , , Stephen Caddick، نويسنده , , N.R Treweeke، نويسنده , , D Pardoe، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
8
From page
6607
To page
6614
Abstract
A new model for the rationalisation of previously reported DKR results is presented. The proposed model is based both on experimental and molecular modelling results which indicate that selectivity arises from the interaction between the leaving group and the stereodifferentiating substituent of the chiral auxiliary.
Keywords
molecular modelling , Ab initio , Transition states , dynamic kinetic resolutions (DKR)
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082265
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