Author/Authors :
A Gil Santos، نويسنده , , Sara X Candeias، نويسنده , , Carlos A.M Afonso، نويسنده , , Kerry Jenkins، نويسنده , , Stephen Caddick، نويسنده , , N.R Treweeke، نويسنده , , D Pardoe، نويسنده ,
Abstract :
A new model for the rationalisation of previously reported DKR results is presented. The proposed model is based both on experimental and molecular modelling results which indicate that selectivity arises from the interaction between the leaving group and the stereodifferentiating substituent of the chiral auxiliary.
Keywords :
molecular modelling , Ab initio , Transition states , dynamic kinetic resolutions (DKR)
