Title of article :
On the coupling reaction of lithium azaenolates of chiral oxazolines with carbonyl compounds
Author/Authors :
Saverio Florio، نويسنده , , Vito Capriati، نويسنده , , Renzo Luisi، نويسنده , , Alessandro Abbotto، نويسنده , , Daniel J. Pippel، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
Optically pure chloromethyloxazolines have been prepared, lithiated and then reacted with benzophenone to furnish stereoselectively oxazolinyl oxiranes and formyl oxiranes. The stereoselection observed has been related to the geometry of the intermediate lithium azaenolates. Calculations have been carried out in order to evaluate the relative stability of the E and Z forms of the lithium azaenolates. The reaction of a lithium azaenolate with other ketones leading to oxazolinyl epoxides is also reported.
Keywords :
lithium and compounds , Oxazolines , Epoxides , computer-assisted methods , enolates
Journal title :
Tetrahedron
Journal title :
Tetrahedron