Title of article
Total syntheses of neuroprotective mastigophorenes A and B
Author/Authors
Yoshiyasu Fukuyama، نويسنده , , Keiji Matsumoto، نويسنده , , Yasutoshi Tonoi، نويسنده , , Ritsuko Yokoyama، نويسنده , , Hironobu Takahashi، نويسنده , , Hiroyuki Minami، نويسنده , , Hiroshi Okazaki، نويسنده , , Yasuhide Mitsumoto، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
9
From page
7127
To page
7135
Abstract
(−)-Herbertenediol (3) which is regarded as a biosynthetic precursor of mastigophorenes A and B has been effectively synthesized from (R)-1,2-dimethyl-2-cyclopentene carboxylic acid by applying an intramolecular Heck reaction to the construction of the quaternary carbon center, and then horseradish peroxidase-catalyzed oxidative coupling of 3 has given rise to (−)-mastigophorenes A and B. Mastigophorenes A and B have been found to exhibit significant neuroprotective activity in primary cultures of fetal rat cortical neurons.
Keywords
mastigophorene , herbertane-type sesquiterpene , Heck reaction , Horseradish peroxidase , neuroprotective activity
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082318
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