Author/Authors :
Yoshiyasu Fukuyama، نويسنده , , Keiji Matsumoto، نويسنده , , Yasutoshi Tonoi، نويسنده , , Ritsuko Yokoyama، نويسنده , , Hironobu Takahashi، نويسنده , , Hiroyuki Minami، نويسنده , , Hiroshi Okazaki، نويسنده , , Yasuhide Mitsumoto، نويسنده ,
Abstract :
(−)-Herbertenediol (3) which is regarded as a biosynthetic precursor of mastigophorenes A and B has been effectively synthesized from (R)-1,2-dimethyl-2-cyclopentene carboxylic acid by applying an intramolecular Heck reaction to the construction of the quaternary carbon center, and then horseradish peroxidase-catalyzed oxidative coupling of 3 has given rise to (−)-mastigophorenes A and B. Mastigophorenes A and B have been found to exhibit significant neuroprotective activity in primary cultures of fetal rat cortical neurons.
Keywords :
mastigophorene , herbertane-type sesquiterpene , Heck reaction , Horseradish peroxidase , neuroprotective activity
