Title of article
Diastereocontrolled synthesis of unit A of cryptophycin
Author/Authors
Cyrille Pousset، نويسنده , , Mansour Haddad، نويسنده , , Marc Larchevêque، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
5
From page
7163
To page
7167
Abstract
Cryptophycin fragment A was prepared in 11 steps from protected methyl (R)-mandelate 4. A diastereoselective addition of magnesium acetylide to methyl mandelate and a Sharpless epoxidation followed by regioselective opening of the resulting epoxide allowed the synthesis of this intermediate in high diastereomeric purity.
Keywords
depsipeptide , diastereoselective epoxidation , Polyol
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082323
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