Author/Authors :
Takashi Sugimura، نويسنده , , Tohru Futagawa، نويسنده , , Masato Yoshikawa، نويسنده , , Toshifumi Katagiri، نويسنده , , Ryoso Miyashige، نويسنده , , Miki Mizuguchi، نويسنده , , Shinya Nagano، نويسنده , , Seiji Sugimori، نويسنده , , Akira Tai، نويسنده , , Takahiro Tei، نويسنده , , Tadashi Okuyama، نويسنده ,
Abstract :
Zinc carbenoid addition to an olefin stereocontrolled by a chiral and remote intramolecular hydroxy group was studied in detail. Stereoselectivity as well as chemical yield of the Furukawa cyclopropanation was dramatically improved by modifications of the procedure of addition of the reagents. The structure of an active species to give the hydroxy-directed product is proposed.
Keywords :
Cyclopropanation , Asymmetric synthesis , zinc carbenoid , Stereocontrol
