Title of article :
A novel synthesis of AZT
Author/Authors :
Christine Gauthier، نويسنده , , Yvan Ramondenc، نويسنده , , Gérard Plé، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Abstract :
A novel synthesis of AZT has been achieved from two commercial available products acetaldehyde and d-mannitol. The originality of the synthesis consists of using the powerful monovinylogation reagent, the 2-lithio-1-trimethylsiloxyethylene, and to introduce the thymine moiety and to build the furanose ring in the same and last step.
Keywords :
Cyclisation , Nucleosides , Azides , Antivirals
Journal title :
Tetrahedron
Journal title :
Tetrahedron
