Title of article
Assessing the scope of the tandem Michael/intramolecular aldol reaction mediated by secondary amines, thiols and phosphines
Author/Authors
Elinor L Richards، نويسنده , , Patrick J Murphy، نويسنده , , Francesca Dinon، نويسنده , , Silvia Fratucello، نويسنده , , Paul M Brown، نويسنده , , Thomas Gelbrich، نويسنده , , Michael B Hursthouse، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
14
From page
7771
To page
7784
Abstract
The outcome of a tandem Michael/intramolecular aldol reaction which is mediated by secondary amines, thiols and phosphines has been found to be highly substrate dependent, with the best results being obtained for the formation of 5 and 6-membered rings using thiol or thiolate nucleophiles. Amine and phosphine mediated cyclisations were found to be problematic in several cases but were still effective methods for the formation of 5–7 membered rings.
Keywords
Thiols , tandem Michael/intramolecular aldol reaction , secondary amine , phosphines
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082392
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