A new approach in the solid-phase synthesis of polyamine derivatives: construction of polyamine backbones from the center

A new and divergent approach for the solid-phase synthesis of polyamines and polyamine derivatives is shown. Monoprotected diamines are coupled to the Merrifield resin and alkylated at the resin-bound benzylic amine with masked ω-aminoalkyl groups. Selective deprotection of either of the two terminal amino functions allows the specific prolongation or derivatization of the resin-bound triamines at the two ends of the molecules.