Title of article
Syntheses of chiral fluorine analogs of hematoporphyrin
Author/Authors
Masaaki Omote، نويسنده , , Akira Ando، نويسنده , , Kazuyuki Sato، نويسنده , , Itsumaro Kumadaki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
10
From page
8085
To page
8094
Abstract
Four chiral fluorine analogs of hematoporphyrin, (R,R)-, (R,S)-, (S,R)-, and (S,S)-3,8-bis(2,2,2-trifluoro-1-hydroxyethyl)deuteroporphyrins, were synthesized starting from pyrroles with a chiral 2,2,2-trifluoro-1-hydroxyethyl (TFHE) group. This chiral TFHE group was obtained by asymmetric reduction of a trifluoroacetyl group. Among these chiral analogs of hematoporphyrin, the (S,S)-isomer showed higher affinity for cancer cells than other stereoisomers.
Keywords
hematoporphyrin , Trifluoromethyl , Fluorine , Pyrrole , Stereoisomers
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082419
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