Title of article
Synthesis of haptens for the development of immunoassays for the monitoring of intracellular anti-HIV nucleosides and nucleotides
Author/Authors
Thierry Brossette، نويسنده , , Emmanuel Klein، نويسنده , , Christophe Créminon، نويسنده , , Jacques Grassi، نويسنده , , Charles Mioskowski، نويسنده , , Luc Lebeau، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
15
From page
8129
To page
8143
Abstract
A series of nine modified dideoxynucleosides and dideoxynucleotides has been synthesized for preparing antigenic conjugates with keyhole lympet haemocyanin in order to produce specific antibodies, and develop immunoassays. Derivatives of ddI, ddA, d4T, 3TC, and the corresponding 5′-O-monophosphates were designed incorporating an amino spacer at the base for conjugation with the proteinic antigenic carrier.
Keywords
3TC , HIV , Enzyme immunoassay , monophosphate , ddI , Dideoxynucleoside , d4T
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082425
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