Title of article
Acceleration of hetero-Michael reaction by symmetrical pentacyclic guanidines
Author/Authors
Kazuo Nagasawa، نويسنده , , Angelina Georgieva، نويسنده , , Hiroki Takahashi، نويسنده , , Tadashi Nakata، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
6
From page
8959
To page
8964
Abstract
Symmetrical pentacyclic guanidines 1a–c and 2 which contain the core skeleton of 13,14,15-isocrmbescidine 800, have been synthesized. In the presence of catalytic amounts of these guanidines 1, the reaction rate of the conjugate addition of pyrrolidine (9) to γ-crotonolactone (10) could be enhanced depending upon the size of the cavities and substituents on tetrahydropyran rings of 1 and 2.
Keywords
pentacyclic guanidine , organic chiral catalysts , 1 , 3-Dipolar cycloaddition reaction , hetero-Michael reaction
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082516
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