Title of article
Design, synthesis and structure of new chiral squaric acid monoaminoalcohols and diaminoalcohols and their use as catalysts in asymmetric reduction of ketones and diketones
Author/Authors
Hai-Bing Zhou، نويسنده , , Ji Zhang، نويسنده , , Shou-Mao Lü، نويسنده , , RU-GANG XIE، نويسنده , , Zhong-yuan Zhou، نويسنده , , Michael C.K Choi، نويسنده , , Albert S.C. Chan، نويسنده , , Teng-Kuei Yang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
9
From page
9325
To page
9333
Abstract
Many chiral squaric acid aminoalcohols and C2-symmetric diaminoalcohols have been synthesized and their in situ formed chiral boron heterocycles have been used as catalysts for the enantioselective reduction of prochiral ketones and diketones by borane to give alcohols with up to 99% enantiomeric excess and 99% yield. The effects of solvent, catalyst–substrate ratio and temperature were also investigated.
Keywords
prochiral ketones and diketones , enantioselective reduction , squaric aminoalcohol and diaminoalcohols , Asymmetric synthesis
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082550
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