Author/Authors :
Ana Escribano، نويسنده , , Concepcion Pedregal، نويسنده , , Rosario Gonz?lez، نويسنده , , Alejandro Fernandez-Martinez، نويسنده , , Keith Burton، نويسنده , , Gregory A. Stephenson، نويسنده ,
Abstract :
The reaction of α,β-unsaturated cyclic ketones with methyl dichloroacetate anion in the presence of DBU leads to the corresponding bicyclic chlorocyclopropanes in a highly diastereoselective fashion. In the cases of 2-cyclopentenone and 2-cyclohexenone the reaction affords exclusively the endo-Cl isomer.
Keywords :
Cyclopropanation , Diastereoselectivity , Michael initiated ring closure , cyclic enones
