Title of article
Synthesis of precursors of iodine-labeled multifunctional ligands containing 2-nitroimidazole for the detection of hypoxic tissues and/or tumors
Author/Authors
Sophie Monge، نويسنده , , Jimmy Sélambarom، نويسنده , , Jean-Pierre Roque، نويسنده , , André A Pavia، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
9
From page
9979
To page
9987
Abstract
Biocompatible multifunctional ligands with telomeric structure containing 2-nitroimidazole as affinity marker and tosylate as precursor of 123I radioactive tracer were prepared. Telomerization of appropriate monomers derived from tris(hydroxymethyl)-acrylamidomethane was performed in the presence of dodecanethiol, and either AIBN or tert-butylperoxide. These conjugates are designed to target hypoxic tissues and tumors.
Keywords
2-nitroimidazole , telomers , Detection , Tumors , hypoxic tissues , 123I
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082620
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