Title of article
The synthesis of l-gulose and l-xylose from d-gluconolactone
Author/Authors
Wen-Bin Yang، نويسنده , , Sachindra S Patil، نويسنده , , Cheng-Hsin Tsai، نويسنده , , Chun-Hung Lin، نويسنده , , Jim-Min Fang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
7
From page
253
To page
259
Abstract
l-Gulose, an essential component for the antibiotic and antitumor activities of bleomycin A2, was synthesized in 47% yield from d-glucono-1,5-lactone. The effective cleavage of acetonides by SnCl2 in the presence of tert-butyldimethylsilyl ethers was of importance in the course of synthesis. Elaboration of d-glucono-1,5-lactone that includes a step of oxidative degradation by Dess–Martin periodinane also afforded a respectable yield of l-xylose.
Keywords
l-Gulose , l-Xylose , Lactone , Oxidation , Tin(II) chloride
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1082703
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