Title of article :
Cytotoxicity and actin-depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and its analogs
Author/Authors :
Hideo Kigoshi، نويسنده , , Kiyotake Suenaga، نويسنده , , Masaki Takagi، نويسنده , , Atsushi Akao، نويسنده , , Kengo Kanematsu، نويسنده , , Noriyuki Kamei، نويسنده , , Youko Okugawa، نويسنده , , Kiyoyuki Yamada، نويسنده ,
Abstract :
Artificial analogs of aplyronine A (), a potent antitumor macrolide, were synthesized and structure–activity (cytotoxicity and actin-depolymerizing activity) relationships were investigated; the side-chain in was found to play a key role in both biological activities.
Keywords :
marine metabolites , Analogs , Synthesis , structure–activity , actin-depolymerizing , cytotoxicty
