Title of article
Synthesis of two stereoisomeric polydentate ligands, trans and cis cyclopentane-1,2-diaminotetraacetic acids, and complexation by 111In and 153Sm
Author/Authors
Sebastien G. Gouin، نويسنده , , Jean-François Gestin، نويسنده , , Kevin Joly، نويسنده , , Anthony Loussouarn، نويسنده , , Alain Reliquet، نويسنده , , Jean Claude Meslin، نويسنده , , David Deniaud، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
6
From page
1131
To page
1136
Abstract
Two polyaminocarboxylic acid chelating agents were synthesized. Complexation properties regarding 111In and 153Sm, two radionuclides suitable for applications in immunoscintigraphy and radioimmunotherapy were investigated. The synthesis of aminodiacetic acid derivatives and involved preliminary stereoselective synthesis of the corresponding amines, cis and trans cyclopentane-1,2-diamines. 111In labelling confirmed the complexation abilities of the two ligands. An additional comparative study to probe the relationship between ligand structure and metal complex was performed with 153Sm.
Keywords
chelating agent synthesis , polyaminocarboxylic acid , cyclopentane-1 , Radionuclides , 2-diamine
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1082784
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