Title of article
Synthesis of 7-azabicyclo[2.2.1]heptane derivatives via bridgehead radicals
Author/Authors
Alberto Avenoza، نويسنده , , Jes?s H Busto، نويسنده , , Carlos Cativiela، نويسنده , , Jes?s M Peregrina، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
5
From page
1193
To page
1197
Abstract
This report shows the versatility and synthetic potential of 7-azabicyclo[2.2.1]heptane-1-carboxylic acid (Ahc) to obtain several bridgehead 1-substituted-7-azabicyclo[2.2.1]heptane derivatives, including halogen derivatives, via bridgehead radical reactions, proving the existence of the bridgehead radical in 7-azabicyclo[2.2.1]heptane systems. Moreover, we have obtained the interesting compound N-benzoyl-7-azabicyclo[2.2.1]heptane, a precursor of epibatidine.
Keywords
Halogenation , radicals and radical reactions , X-ray crystal structures , bicyclic heterocyclic compounds , amino acids and derivatives
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1082791
Link To Document