Asymmetric induction in a new domino reaction of [3,3]-sigmatropic rearrangement of allylic thiocyanates and intramolecular heterocyclisation

A new synthetic route to diastereomerically pure (4S,5S)-4-vinyltetrahydro-1H-2-imidazolethiones via a novel domino reaction of [3,3]-sigmatropic rearrangement of chiral thiocyanates followed by stereoselective intramolecular amine addition to arising isothiocyanates is reported.