Synthesis of glycosylated-β(1-4)-amino(methoxy) and -oxyamino carbohydrate analogues

The synthesis of new oligosaccharides containing nitrogen or oxygen–nitrogen in interglycosidic linkage is described. Several modified β-N- and β-O-N linked disaccharides with glucose or galactose as reducing unit such as lactose or cellobiose analogues have been prepared stereoselectively using two different methods. All these compounds were fully characterised by one and two dimensional NMR studies, mass spectroscopy and the crystallographic structure of Gal-β-N-(1,4)-Gal derivative was obtained. These type of structural modifications of oligosaccharides could be useful for study of various biochemical processes.