Title of article :
Chemoselective reactions of N1-methyl-2-hydroxy-3-methylamino-3-phenylpropanamide with electrophiles. Synthesis of chiral hexahydro-4-pyrimidinones and oxazolidines
Author/Authors :
Chakib Hajji، نويسنده , , Ma Luisa Testa، نويسنده , , Elena Zaballos-Garcia، نويسنده , , Ram?n J Zaragoz?، نويسنده , , Juan Server-Carri?، نويسنده , , Jose Sepulveda-Arques، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Abstract :
The reactivity of (2S,3S)-N1-methyl-2-hydroxy-3-methylamino-3-phenylpropanamide , containing three nucleophilic centres has been studied against dihaloalkanes and aldehydes. Hexahydro-4-pyrimidinones or oxazolidines were obtained chemoselectively. Experimental results were explained by ‘ab initio’ calculations.
Keywords :
pyrimidinones , oxazolidines , Dichloromethane , aminodiols , Regioselectivity
Journal title :
Tetrahedron
Journal title :
Tetrahedron
