Author/Authors :
Khalid A El Sayed، نويسنده , , Khaled Y Orabi، نويسنده , , D.Chuck Dunbar، نويسنده , , Mark T Hamann، نويسنده , , Mitchell A. Avery، نويسنده , , Yogesh A Sabnis، نويسنده , , Jaber S Mossa، نويسنده , , Farouk S El-Feraly، نويسنده ,
Abstract :
Sarcophine () is a furanocembranoid diterpene first reported from the Red Sea soft coral Sarcophyton glaucum with remarkable yields of up to 3% dry weight. Semisynthetic transformation of the lactone to lactam in sarcophine by reaction with benzyl and ethylamine afforded six new N-substituted azasarcophines (), in addition to an asymmetric novel dimer . The in vitro activity of azasarcophines against Palsmodium falciparium (D6 clone) and P. falciparium (W2 clone) are also discussed.
