Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis

A general fluorous thiol quenching method is introduced. Excess α-bromoketones or benzyl bromides in parallel N-alkylation reactions are quenched with a fluorous thiol (C6F13CH2CH2SH). The resulting fluorous derivatives can be separated from the reaction mixture by a solid phase extraction on fluorous silica gel.