Title of article
Synthesis, activity and theoretical study of ABT-418 analogues
Author/Authors
Alberto Avenoza، نويسنده , , Jes?s H Busto، نويسنده , , Carlos Cativiela، نويسنده , , Albert Dordal، نويسنده , , Jordi Frigola، نويسنده , , Jes?s M Peregrina، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
7
From page
4505
To page
4511
Abstract
This report shows the synthesis and biological evaluation of two new conformationally restricted ABT-418 analogues. This restriction is introduced by the incorporation of the 7-azabicyclo[2.2.1]heptane skeleton. Furthermore, we report here a high-level quantum mechanical study of their conformations in the gas phase.
Keywords
biologically active compounds , isoxazoles , molecular modeling/mechanics , bicyclic heterocyclic compounds , amino acids and derivatives
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1083139
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