Nucleosides with furanyl scaffolds

Synthesis of purine and pyrimidine nucleosides with furanyl scaffolds is described. The 2-functionalized tetrahydrofuranol derivatives and were coupled with nucleobases through the Mitsunobu reaction. The methodology developed is general and can also be applied for an efficient synthesis of apionucleosides. In addition, the methodology was used for the synthesis of the unsaturated purine nucleoside . However, when the elimination reaction used to produce was applied to the pyrimidine case, the stable anhydro compound was produced. The structures of and were confirmed by single-crystal X-ray data. Antiviral evaluation was performed.