Title of article
One-pot multi-substrate enantioselective conjugate addition of diethylzinc to nitroalkenes
Author/Authors
Ate Duursma، نويسنده , , Adriaan J Minnaard، نويسنده , , Ben L. Feringa، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
6
From page
5773
To page
5778
Abstract
A multi-substrate approach is used in the copper-phosphoramidite catalyzed enantioselective conjugate addition of diethylzinc to nitroalkenes, using up to nine different nitroalkenes in a one pot procedure. The 18 products (9 times 2 enantiomers of nine different nitroalkanes) can be analyzed by chiral CG in a single run since on overlap in the peaks is observed. The obtained enantioselectivities are amongst the highest reported so far for the catalytic 1,4-addition of dialkylzinc reagents to nitroalkenes.
Keywords
copper , Conjugate addition , phosphoramidities , Asymmetric catalysis , Combinatorial chemistry
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1083273
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