Author/Authors :
Hisatoshi Uehara، نويسنده , , Tohru Oishi، نويسنده , , Masayuki Inoue، نويسنده , , Mitsuru Shoji، نويسنده , , Yoko Nagumo، نويسنده , , Masashi Kosaka، نويسنده , , Jean-Yves Le Brazidec، نويسنده , , Masahiro Hirama، نويسنده ,
Abstract :
Ciguatoxin CTX3C is a representative congener of the ciguatoxins, which are known to be the principal causative agents of ciguatera food poisoning. The structure of CTX3C spans more than 3 nm and is characterized by 13 ether rings. To attain a practical construction of this molecule, efficient supplies of the structural fragments are crucial. Herein we report the convergent synthesis of the HIJKLM ring fragment and present a new carbonyl olefination protocol to cyclize the J ring using low-valent titanium.
Keywords :
Ciguatoxin , Ring-closing metathesis , CTX3C , low-valent titanium complex , polyether , intramolecular carbonyl olefination
