Author/Authors :
Lushi Tan، نويسنده , , Cheng-yi Chen، نويسنده , , Weirong Chen، نويسنده , , Lisa Frey، نويسنده , , Anthony W. King، نويسنده , , Richard D Tillyer، نويسنده , , Feng Xu، نويسنده , , Dalian Zhao، نويسنده , , Edward J.J Grabowski، نويسنده , , Paul J Reider، نويسنده , , Paul OʹShea، نويسنده , , Philippe Dagneau، نويسنده , , Xin Wang، نويسنده ,
Abstract :
Two synthetic strategies to the COX-2 specific inhibitor have been described that allowed its preparation in large quantities in 79% overall yield from (S)-2-hydroxy-2-methylbutyric acid. These studies have led to the identification of an efficient resolution of (±)-2-hydroxy-2-methylbutyric acid and a novel thionyl chloride aided formation of amide from acid .
Keywords :
COX-2 inhibitor , Resolution , Suzuki coupling , hydroxy ketone
