2-(N-Methylanilino)-3-formylchromone—a versatile synthon for incorporation of chromone moiety in a variety of heterocyclic systems and macrocycles through reactions with bifunctional nucleophiles

Reactions of 2-(N-methylanilino)-3-formylchromones with a number of bifunctional nucleophiles, involving substitution of N-methylanilino moiety and/or condensations with 3-formyl function have provided an easy access to a variety of potentially biologically active hetero-annelated chromones, novel macrocycles, and tetradentate ligands having intact chromone moiety.