Title of article :
Fibril-forming model synthetic peptides containing 3-aminophenylacetic acid
Author/Authors :
Samir Kumar Maji، نويسنده , , Debasish Haldar، نويسنده , , Arijit Banerjee، نويسنده , , Arindam Banerjee، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
Pages :
8
From page :
8695
To page :
8702
Abstract :
The FT-IR, 1H NMR, electrospray mass spectrometry studies of several dipeptides containing 3-APA (3-aminophenylacetic acid) and Aib/Val/Pro, revealed that all peptides share a common structural feature, an extended backbone conformation and they form the intermolecular hydrogen bonded supramolecular β-sheet structure in the solid state. The SEM images of all peptides exhibit amyloid-like fibrils, reminiscent of many neurodegenerative diseases like Alzheimerʹs, Prion-protein diseases.
Keywords :
amyloid fibril , 3-aminophenylacetic acid , ?-Sheet , Aib
Journal title :
Tetrahedron
Serial Year :
2002
Journal title :
Tetrahedron
Record number :
1083581
Link To Document :
بازگشت