Author/Authors :
Rufine Akué-Gédu، نويسنده , , Sahar Al Akoum Ebrik، نويسنده , , Anne Witczak-Legrand، نويسنده , , Dominique Fasseur، نويسنده , , Samira El Ghammarti، نويسنده , , Daniel Couturier، نويسنده , , Bernard Decroix، نويسنده , , Mohamed Othman، نويسنده , , Marc Debacker، نويسنده , , Benoit Rigo، نويسنده ,
Abstract :
During attempted Friedel–Crafts cyclization of some arylmethyl pyroglutamic acids or of N-phenacyl prolines, decomposition of the activated form of the acid have been observed, giving new heterocyclic systems. This general decarboxylation occurred when there are difficulties to realize a Friedel–Crafts cyclization and is explained by geometrical or electronic considerations.
Keywords :
Friedel–Crafts reaction , N-acyliminium salts , decarbonylation , Decarboxylation , pyroglutamic acid , N-acylproline , Lactams
