Author/Authors :
Sandra Gemma، نويسنده , , Stefania Butini، نويسنده , , Caterina Fattorusso، نويسنده , , Isabella Fiorini، نويسنده , , Vito Nacci، نويسنده , , Katherine Bellebaum، نويسنده , , Down McKissic، نويسنده , , Ashima Saxena، نويسنده , , Giuseppe Campiani، نويسنده ,
Abstract :
The synthesis of two new Huperzine A analogues is reported. Both products present an amino substituted benzo-fused system in place of the pyridone ring of the natural alkaloid. The synthetic strategy to the two analogues is based on three different key palladium-catalyzed steps, namely a carbonylation reaction, an epoxide isomerization and a bicycloannulation reaction.
Keywords :
Palladium , Carbonylation , epoxide isomerization , bicycloannulation reaction
