Title of article :
Cyclization and rearrangement of 4-(2-methyloxiranyl)-β-lactams promoted by titanocene dichloride/Zn0
Author/Authors :
Josefa Anaya، نويسنده , , Alfonso Fern?ndez-Mateos، نويسنده , , Manuel Grande، نويسنده , , Justo Marti??ez، نويسنده , , Gema Ruano، نويسنده , , Ma Rosa Rubio-Gonz?lez، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2003
Abstract :
Enantiopure epoxyalkene-2-azetidinones derived from d-glucosamine by Staudinger reaction gave on treatment for 2 h with titanoncene (III) monochloride generated in situ, bicyclic and tricyclic β-lactams with high regio and stereo-selectivity but with low conversion. For extended reaction times (15–22 h) a rearranged five-membered ring imide was the main reaction product together with the tribactam.
Keywords :
carbapenam , titanocene , tribactam , epoxy-?-lactams , ring expansion
Journal title :
Tetrahedron
Journal title :
Tetrahedron
