Title of article
Enantioselective synthesis of (−)-idiospermuline
Author/Authors
Larry E. Overman، نويسنده , , Emily A Peterson، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
15
From page
6905
To page
6919
Abstract
The enantioselective total synthesis of the nonacyclic polypyrrolidinoindoline (−)-idiospermuline is described. Stereocontrolled formation of the vicinal quaternary carbon centers is achieved in a single step by dialkylation of an unsymmetrical prostereogenic dienolate with a tartrate-derived chiral dielectrophile. A catalyst-controlled diastereoselective Heck cyclization is employed to form the diaryl-substituted quaternary center.
Keywords
cyclotryptamine alkaloids , dialkylation , vicinal quaternary centers , Heck cyclization
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1084240
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