Title of article
Highly diastereoselective synthesis of arylglycine derivatives via TFA-promoted Friedel–Crafts reactions of phenols with cyclic glyoxylate imines
Author/Authors
Yongjun Chen، نويسنده , , Fei Lei، نويسنده , , Li Liu، نويسنده , , Dong Wang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
6
From page
7609
To page
7614
Abstract
Optically active α-arylglycine derivatives were synthesized by Brønsted acid (TFA)-promoted Friedel–Crafts reaction of various phenols with chiral cyclic glyoxylate imines (), followed by deprotection with Pd(OH)2/C under H2. The diastereoselectivities of the initially formed F–C reaction products are up to 99%.
Keywords
arylglycine , F–C reaction , Phenol , chiral cyclic glyoxylate imine , Diastereoselective synthesis
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1084313
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