Title of article
Improved synthesis of 1,4-dideoxy-1,4-imino-d-galactitol, an inhibitor of E. coli K12 UDP-Gal mutase and mycobacterial galactan biosynthesis
Author/Authors
Duy-Phong Pham-Huu، نويسنده , , Yonas Gizaw، نويسنده , , James N. BeMiller، نويسنده , , Ladislav Petru?، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
5
From page
9413
To page
9417
Abstract
The E. Coli K12 UDP-Gal mutase inhibitor was prepared from d-glucose in 5 steps (42% overall yield). The 4-azido galactose derivative , leading to , was formed by treatment of galactose dithioacetal with mercuric oxide and mercuric chloride in acetone. To obtain , acetal was tosylated or triflated and treated with NaN3.
Keywords
Azasugars , Pd-catalyzed reductive amination , Pyrrolidines
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1084487
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