Author/Authors :
Ashish K. Pathak، نويسنده , , Vibha Pathak، نويسنده , , Manish Kulshrestha، نويسنده , , Darren Kinnaird، نويسنده , , William J. Suling، نويسنده , , S.S Gurcha، نويسنده , , Gurdyal S Besra، نويسنده , , Robert C Reynolds، نويسنده ,
Abstract :
Several octyl 5-O-(α-d-arabinofuranosyl)-α-d-arabinofuranoside disaccharide analogs substituted at the 5-position of the non-reducing end sugar were synthesized and tested in vitro against Mycobacterium tuberculosis (M.tb.), Mycobacterium avium complex (MAC) as well as in a cell free assay system for arabinosyltransferase acceptor/inhibitor activity. A few compounds showed interesting inhibitory activity in the cell free assay as well as against the whole microorganism in vitro.
Keywords :
Glycosyltransferase , Inhibitors , Arabinofuranose , Mycobacterium tuberculosis
