Author/Authors :
Richard E. Lloyd MD، نويسنده , , Michael C Lloyd، نويسنده , , Mark E.B Smith، نويسنده , , Karen E Holt، نويسنده , , Jonathan P Swift، نويسنده , , Philip A Keene، نويسنده , , Stephen J.C Taylor، نويسنده , , Raymond McCague، نويسنده ,
Abstract :
The synthesis of several cyclic amino acids that have all the necessary structural features to make them ideal scaffolds for use in medicinal chemistry is described. A key step in each synthesis is the use of hydrolase enzymes to define a chiral centre. In order to elaborate these building blocks into more complex molecules, crystallization and asymmetric hydrogenation were used to define further stereocentres.
