Title of article :
Asymmetric synthesis of 3(S),17-dihydroxytanshinone
Author/Authors :
Jianhua Xie and Jiangang Zhang، نويسنده , , Wenhu Duan، نويسنده , , Junchao Cai، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
The first synthesis of 3(S),17-dihydroxytanshinone was achieved by ultrasound promoted Diels–Alder reaction of the protected 3-hydroxymethyl-4,5-benzofurandione with a vinylcyclohexene derivative. Bioassay showed that the synthetic 3(S),17-dihydroxytanshinone was active in vitro against HL-60 tumor cell line by MTT method.
Keywords :
Diels–Alder cycloaddition , Total synthesis , Ultrasound , Natural product , Tanshinone diterpene , Antitumor , Dihydroxytashinone
Journal title :
Tetrahedron
Journal title :
Tetrahedron
